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Conclusions This study demonstrates that a three-month folic acid intervention in autistic children participating in structured teaching significantly improved symptoms of autism as measured by ATEC in regards to sociability, and PEP-3 in regards to cognitive verbal/preverbal, receptive language, affective expression, and communication

Compared with the more generalized phenomenological metabolism models, our model features 183 processes: 95 enzymatic reactions

Besides well-established mechanisms that enhance mitochondrial function, we have considered desirable physicochemical properties in selecting the compounds for discussion

Additionally, benfotiamine mitigated oxidative stress and mitochondrial dysfunction and activated Nrf2/ARE pathway in this model, showing its potential to be used in treatment for diseases with tau pathology [21]

Cellular and Molecular Life Sciences, 57(7), 1050-1093

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