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Supplementary Materials Data Availability Statement Data derived from public domain resources: The data presented in this study are available in the Gene Expression Omnibus (GEO) database ( These data were derived from the following resources available in the public domain: GSE21359, GSE76925, GSE38974, GSE173896, (all the links were accessed on 31 October 2025).

doi: 10.1172/jci71180

Maintenance dose: 1 tablet daily, preferably with a meal

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Compounded preparations of AOD-9604 are not lawfully available in the United States as of the date of this listing, and the same restriction position applies under Health Canada's regulatory framework, where no authorized AOD-9604 product exists in any compounding category

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