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Depleted intracellular GSH levels have also been reported in various neurodegenerative disorders such as Alzheimers and Parkinsons disease

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Abnormalities of Homocysteine Metabolism Dysfunctions related to congenital defects in enzymes involved in homocysteine metabolism, to deficiencies in the supply, absorption, or metabolism of folates, vitamins B 12 and B 6 , and to dietary methionine excess all contribute to increasing plasma homocysteine levels (Table 1)