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DOI: 10.1371/journal.pone.0130189 58

UsuiFShirasunaKKimuraHTatsumiKKawashimaAKarasawaTet alInflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm

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It was downregulated in antigen-presenting cells (APCs) isolated from the lungs of patients with this disease and mice exposed to cigarette smoke, thus directing Th1 and Th17 cell differentiation (35, 36)