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doi: 10.3389/fbioe.2024.1343329

In addition, in some cases, TGF- signal transduction can also affect Smad-independent pathways, including Erk, SAPK/JNK and p38 MAPK pathways

A corresponding role for ferroptosis in human ASCVD is also supported by a genetic analysis of human coronary artery plaques which demonstrated a significant positive association between ferroptosis-related gene expression and ASCVD status 80,81

Key Takeaways: Advanced Analytics Orange Book-centric patent landscaping is more efficient for pharmaceutical product analysis than top-down classification-based landscaping, because it starts from the commercially filtered patent set

On the immune side, obesity may cause M2 macrophages ferroptosis due to damage to iron-rich ATMs (MFe hi ) and antioxidant ATMs (Mox), and lead to Treg cells ferroptosis through reductions in NRF2, GPX4, and GCH1 levels