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When NNMT is overactive in adipocytes, SAM is depleted reducing the cells capacity for methylation reactions that regulate gene expression, including the epigenetic programs that control energy expenditure

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Jang J

Potential Benefits (preclinical) Fat metabolism: Animal models report reductions in fat mass while lean muscle is preserved [5] [6]

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Gonzalez-Muniesa P, Martinez-Gonzalez MA, Hu FB, Despres JP, Matsuzawa Y, Loos RJF, Moreno LA, Bray GA, Martinez JA

[DOI] [PMC free article] [PubMed] [Google Scholar] Rini J

Tests in bacteria, cells, and mice all came back negative, suggesting the compound does not pose carcinogenic risk through DNA damage mechanisms