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Cell-culture time courses Cell-culture studies in tendon-derived and fibroblast cell populations report observable changes in cellular migration, proliferation kinetics and gene-expression in growth-factor pathways over a window of hours to several days

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While the emphysema state results in loss of alveolar spaces and low sputum production, the bronchitis phenotype results in narrowing of the airways as well as blocking of the alveolar spaces with mucus obstruction leading to chronic cough, sputum production, and exacerbations (Szalontai et al., 2021