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In PD, mutations in GBA, ATP13A2, and PARK9 impair lysosomal function, leading to -synuclein accumulation and cellular toxicity ( In particular, LRRK2 mutations impair endolysosomal trafficking, contributing to -synuclein clearance failure and promoting neurodegeneration ( 3 Epidemiology and global burden of Parkinsons disease Parkinsons disease (PD) is one of the fastest-growing neurological disorders globally, driven primarily by population aging, environmental exposures, and improved longevity

doi:10.1093/aje/kwv135

Thus, cysteine and GSH decrease the general level of protein ubiquitination

[DOI] [PubMed] [Google Scholar] 171.Puspita L., Chung S.Y., Shim J.-W

Citation: Chang, C

The significant interaction terms were decomposed by a simple slope analysis