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Knockdown of BMAL1 affected the vitality of ECs and significantly inhibited cell proliferation

P.RuizA

Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells ( As a case in point, Li and co-workers loaded dihydroartemisinin (DHA) into iron-based MOFs to design a peroxidase-like nanoreactor (termed DHA@MIL-101 NR) for synergistic CDT-ferroptotic therapy (Figure 5C) ( 3+ , achieving GSH consumption-mediated redox reaction and Fe 2+ -mediated Fenton reaction (Figure 5D)

2 Antibiotics and antibiotic resistance In the pre-antibiotic era, more than half of deaths were attributable to infections (Johnston and Badran, 2022

10.1053/jhep.2000.9602

Rather, they reinforce the concept that micronutrient status may have greater functional relevance in metabolically altered states, where even small imbalances could contribute to underlying pathophysiological processes