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during chromosome replication, DNA-replicating enzymes cannot continue replication to the very end of the chromosome, so with each replication the chromosome end is shortened (this is because the synthesis of fragments requires the attachment of RNA primers to the lagging strand)

Furthermore, LC stimulated the TAU uptake and TAUT expression in VSMCs

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This review paper intends to put together and discuss the spectrum of chemotherapy-induced peripheral neuropathy (CIPN) characteristics so as to highlight areas of future research to pursue on the topic