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The titration schedule then steps up every 4 weeks so the body can adjust before higher doses are reached

In hepatocytes, Hcy can be remethylated to generate methionine by methionine synthase (MS), which requires normal levels of folate and vitamin B 12 , and betaine homocysteine methyltransferase (BHMT), which requires betaine

1 Original Procognitive Characterization McCoy et al., Journal of Pharmacology and Experimental Therapeutics (2013) This paper has been under Expression of Concern since 2021 (see disclosure block above)

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