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doi: 10.1093/carcin/bgi337

The enzyme is membrane-bound with its active site facing the external side of the cell

Lowered level of de-glycating enzymes is linked with neurodegeneration Cells or tissues have evolved enzymatic mechanisms to detoxify AGEs with the help of various enzymes

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Kato Y, Kubo Y, Iwata D, Kato S, Sudo T, Sugiura T, Kagaya T, Wakayama T, Hirayama A, Sugimoto M, Sugihara K, Kaneko S, Soga T, Asano M, Tomita M, Matsui T, Wada M, and Tsuji A

System xc cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS
