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Since synapse formation is an activity-dependent process these findings may be relevant to changes in overall excitatory activity of pyramidal neurons

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Largely elevated levels of circulating IGF-I but as a result of absence of proteolysis of IGFBP-5 and IGFBP-3, necessary for disruption of ternary complex formation, IGF-I bioactivity in serum is low and presumably tissue bioactivity of IGF-I (and IGF-II) is low

Adding 1 mL gives 5 mg/mL and adding 2 mL gives 2.5 mg/mL

Chapter 11: Presenting results and Summary of findings' tables

Once repair cells reach the injury, they need to become the right type of cell