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J.KovacsP.BlakelyL

EC4 cells were grown in high glucose DMEM supplemented with 10% fetal bovine serum and 1 each of glutamine, nonessential amino acids, and sodium pyruvate

First, we confirmed the ability of WZ-1 to induce recombinant WDR5 protein oligomerization in vitro using immunoblotting

Furthermore, the hyperactivation of neutrophils results in the generation of substantial quantities of ROS, which can rapidly deplete oxygen and nutrients in the surrounding microenvironment, as well as induce lipid peroxidation, thereby compromising the integrity of cellular membranes and organelles

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Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome