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Colombo SL, Palacios-Callender M, Frakich N, Carcamo S, Kovacs I, Tudzarova S, Moncada S

Nevertheless, no inhibitor has yet reached phase I clinical trials and further efforts are needed to circumvent all obstacles related to absorption, metabolism and various issues on pharmacokinetics in order to eventually achieve orally bioavailable drug candidates acting as cognitive enhancers in vivo

If the dark color stays, pigmentation may be the primary cause, and topical treatments or laser therapy may be a better starting point

STARD7 deficiency also triggers ER stress which is also known to promote ROS production, as demonstrated in hepatocarcinoma-derived HepG2 cells as well as in triple negative breast cancer-derived MDA-MB231 cells (Flores-Martin et al, 2016

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Personalized medicine and neurodegeneration As the field moves towards personalized medicine, understanding individual variability in brain metabolism will be crucial for developing targeted treatments