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[DOI] [PubMed] [Google Scholar] 142.Hartz A.J., Bentler S., Noyes R., Hoehns J., Logemann C., Sinift S., Butani Y., Wang W., Brake K., Ernst M., Kautzman H

Zhou J, Zhang W, Liang B, Casimiro MC, Whitaker-Menezes D, Wang M, et al

Quercetin The antioxidant quercetin is one of the most abundant polyphenolic flavonoids and displays beneficial biological effects in many diseases

There are multiple drugs that can promote the degradation of its protein: HSP90 inhibitors (e.g., 17-allylamino-17-demethoxygeldanamycin), class II histone deacetylase (HDAC) inhibitors and the thioredoxin inhibitor (e.g., PX-12), which cause ubiquitination and the proteasomal degradation of HIF-1

NAC, a prodrug that supplies bioavailable cysteine necessary for the replenishment of GSH, is routinely administered clinically to overcome pharmacologically induced GSH deficiency 22,23

Article CAS Google Scholar Beaglehole, R