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Theoretically, the use of pure -adrenergic receptor agonists, such as isoproterenol, and, to a lesser extent, dobutamine, is controversial as this may worsen hypotension mediated by 2-adrenergic receptor agonist-induced peripheral vasodilation

It provides a compelling option for patients who may need an extra edgethose struggling with fatigue, seeking to optimize their body composition, or needing enhanced metabolic support

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However, no randomized controlled trial has been conducted to support the efficacy of nonpharmacological therapy

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