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Many years later, a physician named Shinya Yamanaka was pursuing his training in orthopedic surgery when he began to notice how many diseases and conditions exist that physicians actually have no ability to fix or heal (including everything from spinal cord injuries and traumatic brain injuries to orthopedic conditions and autoimmune diseases), and he lost confidence in the surgical approach and instead turned his efforts towards curing diseases from a much more thoughtful scientific approach, which ultimately resulted in one of the greatest discoveries of all time (winning a Nobel Prize in 2012): mature adult cells can in fact be reverted back to a full pluripotent stem cell state, capable of becoming any type of cell or tissue, by just introducing a few simple factors into the cell [104]

The cellular redox homeostasis comprises the GSH-regulated antioxidative defense

Upstream and downstream mechanisms for the promoting effects of IGF-1 on differentiation of spermatogonia to primary spermatocytes

Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism 29

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doi: 10.3892/ijmm.2017.3127