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The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible

Proceedings of the National Academy of Sciences of the United States of America 2019;116, 22624-22634, doi:10.1073/pnas.1915905116

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VB12 (0.5 mg/day) or vehicle was injected intravenously at 12:30 h for 11 days, which was followed by oral administration (2 mg x 3/day) for 7 days

Following subcutaneous injection, the peptide rapidly enters systemic circulation with peak concentrations achieved in approximately three to six minutes

PRP, on the other hand, is anabolic it delivers active growth factors that recruit stem cells, stimulate fibroblasts, and encourage the formation of healthy new collagen