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These enzymes can bind to collagen, and even to hormones and cytokines, and degrade them

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[DOI] [PubMed] [Google Scholar] 19.MacQuarrie R, Bernhard SA

Consequently, the expression of COX-2, iNOS, TNF-, IL-1, and IL-6 is attenuated, accompanied by reduced MMP and elastase activities that preserve extracellular-matrix integrity and tissue elasticity [265,267]

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