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Protocols, doses, and reactions reported below come from clinical trials and community sources

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Patients in their late 30s to early 50s who have begun noticing collagen loss but have not yet developed deep structural atrophy represent the sweet spot

The compounds that survive institutional scrutiny tend to be the ones that happened to be in the hands of practitioners who were already organized enough, connected enough, and capitalized enough to run an evidence-gathering operation on something that costs almost nothing to compound

In a subset of rat layer 5 ACC pyramidal neurons, DOR, but not MOR, activation produces direct hyperpolarization, presumably through a postsynaptic increase in potassium conductance (Tanaka and North, 1994)
