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The biosynthesis pathway of AX in Phaffia yeast is catalyzed by specific monooxygenase enzymes belonging to the P450 family, such as CrtS/Asy, along with a reductase enzyme

Interestingly, a specific GPX1 polymorphism resulting in a proline-to-leucine transition at position 198 (Pro198Leu) is associated with a reduction in GPx1 activity and found to be more prevalent in Keshan patients

J Am Chem Soc 129:84388439 Bhirde AA, Patel V, Gavard J, Zhang G, Sousa AA, Masedunskas A, Leapman RD, Weigert R, Gutkind JS, Rusling JF (2009) Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery

Yang H, Qin D, Xu S, He C, Sun J, Hua J, Peng S

Another study suggests a combination of strength and cardio increases glutathione the most in comparison to cardio and strength training alone (15)

[DOI] [PMC free article] [PubMed] [Google Scholar] [49].Moreno-Sols G, Torre-Aguilar MJD, Torres-Borrego J, Llorente-Cantarero FJ, Fernndez-Gutirrez F, Gil-Campos M, et al