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However, excessive oxidative stress may impair the autophagylysosomal pathway and even lead to lysosomal membrane leakage, ultimately resulting in autophagic cell death [109, 110]

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N -acetylcysteine (NAC) which is commonly used as the antidote to acetaminophen in overdose scenarios is a tolerable and safe drug that effectively reduces free radicals and other oxidants [14,15,16]

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