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further suggest that the dual impairment of the intestinal and blood-brain barriers establishes a critical gut-brain axis pathway that jointly promotes disease progression (9)

A number of techniques have been used to destabilize QS, including preventing the synthesis of acyl-homoserine lactones (AHLs), decreasing the activity of the AHL synthase, disrupting and inactivating AHLs, and using several antagonists signalling compounds from competitors [65,144]

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Overall, it is clear that in leaves, ascorbate, in collaboration with the thiol system, has a role in protection against reactive oxygen species produced during photosynthesis [212]

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