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Mechanistically, this approach leverages chemotherapy to induce immunogenic cell death, whereby the release of danger signals and tumor antigens boost the anti-cancer efficacy of immunotherapy (234)

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While the threshold level could be extended only to 35 min with hydroxocobalamin (300 mg/kg i.v.) the protective action of sodium thiosulphate (100, 500 and 1000 mg/kg i.v.) persisted dose dependently for about 1, 2 and 4 h, respectively

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