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[7] (This interaction is not significant when levodopa is combined with carbidopa, as in standard carbidopa/levodopa therapy, because carbidopa prevents peripheral levodopa breakdown.) Another notable interaction involves the chemotherapeutic agent altretamine: coadministration of pyridoxine can decrease altretamines effectiveness and is generally advised against unless specifically directed

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Ultimately, future progress depends on closer cross-disciplinary collaboration, which brings together toxicology, oncology, environmental science, and public health to design integrated strategies for prevention, detection, and intervention

settlements of, 2526, 27, 28