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Nat Chem Biol 16:497506 Gaschler MM, Andia AA, Liu H, Csuka JM, Hurlocker B, Vaiana CA et al (2018) FINO(2) initiates ferroptosis through GPX4 inactivation and iron oxidation

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There are two heme-containing structures with iron metal atoms, one called cytochrome c1 with one heme group and another called cytochrome b with two heme groups

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The results of the trial demonstrated that the average Total Symptom Score, stabbing and burning pain, and neuropathy symptoms decreased significantly in all three treatment groups compared to those under control