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Differentiation of macrophages For M0 macrophage differentiation, human THP-1 monocytes were treated with 12-O-tetradecanoylphorbol-l3-acetate (PMA

Both crystallography studies and structural models suggest that IgG binds to FcRn in an upside-down orientation, such that the Fab arms face down towards the membrane in which FcRn is embedded [34, 61]
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