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Discovery of bisubstrate inhibitors of nicotinamide N -methyltransferase (NNMT)

When a compound average effect is only 2 kilograms over 12 weeks, many individual participants likely saw minimal to no change, while a smaller subset may have responded more strongly, pulling the average up

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The gut-brain axis is complex, and altering gut hormone signaling can have downstream effects on neurotransmitter systems that influence mood and emotional regulation

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