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doi: 10.2337/db07-0013 89 AllenDAHarwoodSVaragunamMRafteryMJYaqoobMM

While these findings strongly support macrophage-targeted repurposing strategies in colorectal cancer, similar immunosuppressive mechanisms are also prominent in other highly lethal malignancies

Impaired antioxidant defenses, characterized by reduced activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT), along with decreased glutathione levels, are commonly observed in patients with polycystic ovary syndrome (PCOS), endometriosis, and idiopathic infertility (43, 77, 8587)

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In these cases one must infer that the G6PD() state is a selective disadvantage for hematopoietic stem cells
