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Microsomal GST1 (MGST1) and GSTP1-1, which are frequently overexpressed in cancer cells, contribute to DOX resistance

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altered the extension substrate of DEBS M6+TE by exchanging the AT domain with those that can accept sterically bulkier extender substrates, such as phenylmalonyl-CoA, isopentylmalonyl-CoA, and hexylmalonyl-CoA

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Moreover, epidemiologic studies show a significantly increased risk of Crohns disease and ulcerative colitis [137,138,139]

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