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Regardless of the cause of the deficiency, initial treatment with parenteral B12 was regarded as the first choice for patients with acute and severe manifestations of B12 deficiency

It is important to emphasize that activation of the JAKSTAT3 pathway and the upregulation of GFAP should not be interpreted as substate-specific markers of astrocyte reactivity 139
Available online at: 93 GrahamJ.LeonardJ.BanerjiS.WangG

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Age, family history, and the presence of the apolipoprotein E 4 allele have been found to be significant risk factors for the development of Alzheimer disease and all-cause dementia.1-3 More recently, a high plasma concentration of homocysteine has also been shown to be a risk factor for Alzheimer disease and dementia.4 Docosahexaenoic acid (DHA), an -3 polyunsaturated fatty acid found in some foods and many tissues in the body, also appears to be important in affecting the risk of dementia

Verma, A., Hirsch, D., Glatt, C., Ronnett, G
