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Pierno S, Camerino GM, Cannone M, Liantonio A, De Bellis M, Digennaro C, Gramegna G, De Luca A, Germinario E, Danieli-Betto D, Betto R, Dobrowolny G, Rizzuto E, Musaro A, Desaphy JF, Camerino DC (2014) Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice

It comprises 93 items, and evaluates childs early development, development of language, functioning of language and communication, loss of speech and motor skills, social development and play, interests and behavior

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In the experimental setting, this is accomplished by an enriched environment (EE), comprising large cages with toys, tubes, ladders, and larger groups of animals with the opportunity for more complex social interaction that activates various neural networks of the brain