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Alopecia Areata is an autoimmune disorder where the immune system mistakenly attacks the hair follicles, leading to hair loss in small, round patches

It plays an important role in maintaining oxidative balance and supporting normal cellular protection processes involved in managing everyday metabolic and environmental stress

In Fitzpatrick III through V skin, common in Hispanic, Caribbean, and Mediterranean populations, PIE often presents differently than the classic pink or red appearance: Marks may look violet, dusky pink, or dark plum rather than bright red The blanch test still works (vascular marks blanch regardless of skin tone), but the color shift may be subtle and harder to see PIE frequently coexists with PIH in the same lesion, creating a layered red and brown appearance Both pathologies require concurrent treatment, not sequential When we evaluate PIE in patients with deeper skin tones at our Doral clinic, we adjust the protocol in three ways

J Neurosci 24:66866692

Wu J, Stoica BA, Dinizo M, Pajoohesh-Ganji A, Piao C, Faden AI

[DOI] [PubMed] [Google Scholar] 62.Akoumianakis I., Antoniades C
