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10.1016/j.regpep.2009.05.008 3 BarisicI.BalenovicD.KlicekR.RadicB.NikitovicB.DrmicD.et al (2013)

While research indicates that it does not significantly impact growth hormone levels, IGF-1, or glucose metabolism, long-term studies on its safety are still limited

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IC/PBS usually occurs with not only pain, but significant urgency to urinate with many patients having frequency to void over 20 times per day, although little urine will be released

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doi: 10.1146/annurev.arplant.53.100301.135154