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PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024

By analyzing experimental and computational data, it can uncover key structureactivity relationships, predict catalytic performance, and guide experimental design 221,222

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Neuron 66 , 101113 (2010)

But it comes in a few different forms and works with an enzyme that has a very similar name

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