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When SHBG goes down, the amount of free testosterone the bioavailable, active portioncan go up

Long-term studies show no evidence of organ toxicity or significant side effects
Cagnacci A, Soldani R, Laughlin GA, Yen SS

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

In contrast, fat-soluble vitamins can build up in bodily tissue and cause overdose symptoms
