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In addition to shaping the bile acid pool, the gut microbiota produces a substantial quantity of metabolites that can have a vast impact on the host

A meta-analysis of the ELIXA, LEADER, SUSTAIN-6, EXSCEL, Harmony Outcomes, REWIND, PIONEER 6, and AMPLITUDE-O trials involving over 60,000 patients with T2DM demonstrated an 11% decrease in HF hospitalization (Sattar et al

Interestingly, the mid-section of tirzepatide also possesses a lysine residue to facilitate the 20-carbon fatty diacid, while NNC00902764 has a fatty-acyl group with a monoacid at the C-terminus

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10.1097/MD.0000000000034978 [DOI] [PMC free article] [PubMed] [Google Scholar] 44

With the mission of "continuous innovation for better life", the company focuses on major disease therapeutic areas such as oncology, anti-infectives, central nervous system (CNS), metabolism and immunology