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With aging, SN neurons in primates gradually transition from dopaminergic neurons, identified by the presence of the DA-synthesizing enzyme tyrosine hydroxylase (TH), to dopaminergic neurons expressing neuromelanin and eventually to cells that do not synthesize dopamine (TH-negative) but have neuromelanin [4]

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The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19
