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The overexpression of steroid-sulfatase in elderly women can lead to an estrogen production higher than in men even after menopause

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Bang P, Stangenberg M, Westgren M, Rosenfeld RG

This effect is largely due to the expression of the human oligopeptide transporter 1 (Pept-1) located in the luminal microvilli membrane of the enterocytes [180], and in a lesser extent, through paracellular mechanisms and cell-penetrating peptides translocation [181,182] (Figure 4)

These translocated materials enter the portal circulation and, eventually, the systemic circulation, where they can interact with various immune cells and trigger inflammatory responses (Stewart et al., 2017)

Pycnogenol : In a study in psoriasis patients, the addition of pycnogenol to standard treatment resulted in significant improvement in skin redness, hardening, and scaling compared with standard treatment alone