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Avoid using with retinoids: Retinol, tretinoin, and other retinoids increase cell turnover, which may cause excessive irritation when combined with copper peptides

However, most research connecting acupuncture and hypothyroidism consists of individual case studies, so larger-scale studies are needed to confirm this correlation

doi: 10.1016/j.conb.2017.11.006 44 GreenbaumD.ColangeloC.WilliamsK.GersteinM

Science 322 , 12111217 (2008)

Mischley LK, Conley KE, Shankland EG, Kavanagh TJ, Rosenfeld ME, Duda JE, et al

Research has identified potential interactions with NMDA receptor modulation and MAPK signalling pathways, with data suggesting structural homology to glucocorticoid-induced leucine zipper (GILZ) a protein involved in anti-inflammatory and immune-regulatory signalling via the ERK pathway