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Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies

WON-21 and its components exerted antioxidant and anti-inflammatory effects

This Review highlights the central role of astrocytes in brain lipid homeostasis and reviews evidence for astrocytic lipid dysregulation in various neurodegenerative diseases, including Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, frontotemporal dementia and Huntington disease

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