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Choline contributes to the maintenance of normal liver function

Cell Mol Life Sci

For example, Quant et.al showed that the attachment of succinyl-CoA to the catalytic cysteine residue on HMGCS2 blocks the binding of acetoacetyl-CoA to the substrate

Abbreviations AD Alzheimers disease ALS Amyotrophic lateral sclerosis APOE Apolipoprotein E ATP adenosine triphosphate HB beta-hydroxybutyric acid FA fatty acids GABA gamma-amino butyric acid KB ketone bodies KD Ketogenic diet MAD Modified Atkins diet MCT medium-chain triglyceride MS multiple sclerosis PD Parkinsons disease PEO progressive external ophtalmoplegia PPAR peroxisome proliferator activated receptor PUFA polyunsaturated fatty acids RCT randomized controlled trial ROS reactive oxygen species SGLT2 sodium-glucose cotransporter-2 UCP uncoupling proteins VLCKD very-low-carbohydrate ketogenic diet

RS and HL drafted and critically revised the manuscript

Gastrointestinal Effects Digestive discomfort is the most frequently reported issue with acetyl-L-carnitine supplementation