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This is thought to be due to a heightened perception of pain, called central sensitization

Isoniazid, penicillamine, and some seizure drugs (like phenytoin) may lower vitamin B6 levels, so your provider may adjust doses

The phosphorylated form of NAD + , NADP/NADPH, parallels NAD + /NADH by functioning as a redox coenzyme in the pentose phosphate pathway, generation of acetyl coenzyme A (acetyl-CoA) for lipid and cholesterol biosynthesis, and in the glutathione and thioredoxin antioxidant systems 4,5,8,9