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Description
Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene

Unlike slower-digesting proteins, whey quickly delivers amino acids to muscles when they need them most - immediately after exercise

Red sweet pepper (especially raw) Beet greens (especially cooked) Zucchini (especially cooked) Broccoli (especially boiled) Asparagus (especially cooked) Chard (especially raw) Kale (especially raw) Spinach (especially raw) Vitamin E can reduce markers of oxidative stress and improve antioxidant defenses

Excessive intake may lead to intensified side effects like severe diarrhoea, stomach cramps, or nausea

The second stage is Trem2-dependent and is marked by increased expression of genes involves in lipid metabolism and phagocytic pathway genes (e.g., Lpl, Cst , and Cd9 ), causing excessive inflammatory responses and neurodegeneration (Keren-Shaul et al., 2017

GSH degradation occurs extracellularly, with -glutamyl transferase cleaving the -bond in GSH, GSSG, and conjugates, releasing Cys, forming -glutamyl amino acids and cysteinylglycine (CG)
