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Insulin/IGF-1 have potent roles in promoting bone regeneration, and therapeutic delivery of the factors should be beneficial

J Biol Chem 281(9):56575667

Studies show this combination is a powerful anti-aging duo

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346 FOXO4-DRI inhibits renal tubular senescence and restores renal function in vivo 347

This inhibition prevents the release and nuclear translocation of the NF-B p65 subunit, thereby attenuating downstream inflammatory signaling (256, 257)