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After one year: Continued max dose: weight loss essentially fully maintained Stepped down to 5 mg: weight loss largely maintained, with an average regain of about 12 pounds Switched to placebo: large regain, with roughly 67% of patients eventually requiring rescue therapy That 12-pound tradeoff is the answer to the question patients ask most often: What does it actually cost me to step down

10.1016/s0090-8258(21)01249-x Kristina Roloff, Kristina Nalbandyan, Suzanne Cao, C Camille Okekpe, Inessa Dombrovsky, Guillermo J Velenzuela

It is recommended to take two capsules daily at least half an hour before meals or two hours after meals

Li Y, Yang P, Ye J, Xu Q, Wu J, Wang Y

Consequently, short, thick leads often feel stronger than long, thin ones