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Rowley CA, Kendall MM

Spine immobility from fibrosis and ossification is a major complication Vision damaging eye inflammation can also occur Fracture of fused spine can lead to damage to the spinal cord Stiffness of the spine and chest wall can make breathing difficult Inflammation of aorta or major artery coming from heart Inflammation of the kidney is rare Early heart disease due to chronic inflammation leading to heart attacks can occur in ankylosing spondylitis Early and effective therapy can prevent most of these complications

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Increased Focus on Personalized Medicine Development in genomics and biomarkers are allowing more personalized approaches to senolytic therapies