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D., Siani, A

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Given that suppressing mTOR expression inhibits PNI in pancreatic cancer, we speculated whether mTOR is required for the HGF/c-Met signaling pathway to exert its promoting effects on PNI in pancreatic cancer

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Taken together, these data not only point to a role for CAPS2 in regulating BDNF secretion, but also demonstrate how dysregulation of CAPS2 results in autism-related behaviors in rodent models and human patients

Therefore, in this review our aim is to bring all IGF-1 information regarding metabolism together with the objective of offering clear insight into the issuethis way clarifying how miss-regulation of the GH/IGF-1/insulin axis can lead to metabolic disorders such as MetS and diabetes