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TMAO may induce defects in synaptic plasticity through the PERK signaling pathway mediated by ERS

Funding Funding for this work was provided by the NIH/National Institute of General Medical Sciences (GM114282, GM124072, GM120351, and GM134949), the Volkswagen Foundation (grant 93091), and the Human Frontiers Science Program (RGP0059/2019)

& Smith, R.L

Dorczok MC, Mittmann G, Mossaheb N, Schrank B, Bartova L, Neumann M, et al

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Side effects also increase with dose, primarily gastrointestinal symptoms like nausea, vomiting, and diarrhea
